Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: Insights into the antagonism of the hypolipidemic agent <em>Z</em>-guggulsterone期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: Insights into the antagonism of the hypolipidemic agent Z-guggulsterone

Authors:	Liping Yang David Broderick Yuan Jiang Victor Hsu Claudia S. Maier

Affiliation:	1. Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA;2. Department of Statistics, Oregon State University, Corvallis, OR 97331, USA;3. Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA

Abstract:

Keywords:	HDX, hydrogen/deuterium exchange LC&ndash ESI-MS, liquid chromatography electrospray ionization mass spectrometry FXR-LBD, farnesoid X receptor ligand binding domain LBC, ligand binding cavity CDCA, chenodeoxycholic acid GG, Z-guggulsterone 6ECDCA, 6-ethylchenodeoxycholic acid UDCA, ursodeoxycholic acid DMSO, dimethylsulfoxide TCEP, Tris (2-carboxyethyl) phosphine hydrochloride TOF, time of flight PPARγ, peroxisome proliferator-activated receptor RXR, retinoid X receptor THR, thyroid hormone receptor ER, estrogen receptor VDR, vitamin D receptor GR, glucocorticoid receptor
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