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Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison
Authors:Dmitry Ghilarov  Clare EM Stevenson  Dmitrii Y Travin  Julia Piskunova  Marina Serebryakova  Anthony Maxwell  David M Lawson  Konstantin Severinov
Institution:1. Centre for Life Sciences, Skolkovo Institute of Science and Technology, 143026 Moscow, Russia;2. Institute of Gene Biology of the Russian Academy of Sciences, 119334 Moscow, Russia;3. Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Cracow, Poland;4. Department of Biological Chemistry, John Innes Centre, NR4 7UH Norwich, UK;5. Department of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia;6. A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia;7. Waksman Institute for Microbiology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Abstract:
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  • Keywords:antibiotic  protein complex crystal structure  DNA gyrase  RiPP  LAP  azole synthetase  cyclodehydratase  heterocyclase  dehydrogenase
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