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Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability
Authors:Federico Teloni  Jone Michelena  Aleksandra Lezaja  Sinan Kilic  Christina Ambrosi  Shruti Menon  Jana Dobrovolna  Ralph Imhof  Pavel Janscak  Tuncay Baubec  Matthias Altmeyer
Institution:1. Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland;2. Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland;3. Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 143 00 Czech Republic;4. Life Science Zurich Graduate School (LSZGS), 8057 Zurich, Switzerland
Abstract:
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  • Keywords:replication stress  checkpoint activation  ATR  origin firing  replication catastrophe  pre-mRNA processing  RNA:DNA hybrids  R-loops  gene gating  cleavage  polyadenylation
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