Pain threshold and morphine activity in vitamin D-deficient rats |
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Authors: | C Bazzani R Arletti A Bertolini |
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Institution: | Institute of Pharmacology, University of Modena, via G. Campi 287, I 41100 Modena, Italy |
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Abstract: | In rats, vitamin D-deficiency increases basal pain threshold and the analgesic effect of morphine (hot plate test). Cholecalciferol (1000 I.U./Kg/day s.c.x 5 days) restores pain sensitivity in vitamin D-deficient rats and brings the analgesic effect of morphine back to normal. On the other hand, tolerance to morphine develops faster in vitamin D-deficient rats, this effect too being prevented by cholecalciferol treatment. These data suggest a role for vitamin D status in pain sensitivity and opiate activity. |
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