Delipidated retroviruses as potential autologous therapeutic vaccines--a pilot experiment |
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Authors: | Kitabwalla Moiz Ansari Aftab A Villinger Francois Akeefe Hassibullah Conner Adam P Mayne Ann E Hildreth James E K |
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Institution: | Lipid Sciences, Inc., 7068 Koll Center Parkway, Suite 401, Pleasanton, CA 94566, USA. mkitabwalla@lipidsciences.com |
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Abstract: | This pilot experiment in a simian immunodeficiency virus (SIV) chronic infection model aimed at extending our previous findings that vaccination with delipidated SIV resulted in more potent and diversified antiviral responses (1). Macaques chronically infected with SIVmac239 treated with antiretroviral therapy (ART) were vaccinated with autologous delipidated virus via consecutive lymph node targeted immunizations-1, 1 and 10 mug of virus spaced monthly. Results showed all animals had lasting viral load reduction approaching 1 log compared to set-point, and disease delay. Delipidation may enhance processing/ presentation of viral antigen eliciting potent antiviral control even at such late infection stage. |
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