Effect of salt-loading on erythrocyte deformability in spontaneously hypertensive and Wistar-Kyoto rats |
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| Authors: | K Murakawa M Kohno K Yasunari K Yokokawa N Kurihara T Nagasawa Y Kinoshita T Takeda |
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| Institution: | First Department of Internal Medicine, Osaka City University Medical School, Japan. |
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| Abstract: | Effects of salt-loading on erythrocyte and erythrocyte ghost deformabilities were measured by laser diffractometry using a flat cell and a helium-neon laser in spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY). Salt-loading did not affect the deformability of erythrocytes in SHR and WKY, although a significantly reduced deformability was observed in salt-loaded SHR compared with values in control WKY and salt-loaded WKY (p less than 0.05, p less than 0.05, respectively). In contrast, salt-loading significantly reduced the deformability of erythrocyte ghosts in WKY and SHR (p less than 0.05, p less than 0.05, respectively). Our results suggest that salt-loading reduces erythrocyte membrane viscoelasticity in both WKY and SHR, and that the observed reduction of ghost deformability induced by salt-loading may influence the peripheral circulation. |
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