|
|||||
|
|
Toll-like receptor and antimicrobial peptide expression in the bovine endometrium |
|
| Authors: | Darren Davies Kieran G Meade Shan Herath P David Eckersall Deyarina Gonzalez John O White R Steven Conlan Cliona O'Farrelly I Martin Sheldon |
| Institution: | (1) Department of Veterinary Clinical Sciences, Royal Veterinary College, Royal College Street, NW1 0TU London, UK;(2) Comparative Immunology Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland;(3) Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Rd, G61 1QH Glasgow, UK;(4) Institute of Life Science, School of Medicine, Swansea University, SA2 8PP Swansea, UK |
| Abstract: | BackgroundThe endometrium is commonly infected with bacteria leading to severe disease of the uterus in cattle and humans. The endometrial epithelium is the first line of defence for this mucosal surface against bacteria and Toll-like receptors (TLRs) are a critical component of the innate immune system for detection of pathogen associated molecular patterns (PAMPs). Antimicrobial peptides, acute phase proteins and Mucin-1 (MUC-1) also provide non-specific defences against microbes on mucosal surfaces. The present study examined the expression of innate immune defences in the bovine endometrium and tested the hypothesis that endometrial epithelial cells express functional receptors of the TLR family and the non-specific effector molecules for defence against bacteria. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |