Multicellular Ascomycetous Fungal Genomes Contain More Than 8000 Genes |
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Authors: | Doris M Kupfer CAdonis Reece Sandra W Clifton Bruce A Roe Rolf A Prade |
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Institution: | aDepartment of Biochemistry and Chemistry, University of Oklahoma, Norman, Oklahoma, 73019-0390;bDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma, 74078-0289 |
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Abstract: | Fungi comprise a large monophyletic group of uni- and multicellular eukaryotic organisms in which many species are of economic or medical importance. Fungal genomes are variable in size (13–42 Mb), and multicellular species support true spatial and temporal cell-type-specific regulation of gene expression. In a 38.8-kbAspergillus nidulanscontiguous genomic DNA region, a transposable element and 12 potential genes were identified, 7 similar to genes in other organisms. This observation is consistent with the prediction that multicellular ascomycetous fungi harbor 8000–9000 genes in a 36-Mb average genome. Thus, the genomic DNA sequence of filamentous fungi will provide substantial amounts of genetic and functional information that is not available in yeast, for the human and other metazoan minimal gene complement. |
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Keywords: | fungi genomics gene function Aspergillus Emericella development cell biology DNA sequencing ascomycetes proteome |
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