The effect of fifteen biocides on formaldehyde-resistant strains ofPseudomonas aeruginosa |
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Authors: | M Sondossi H W Rossmoore J W Wireman |
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Institution: | (1) Department of Biological Sciences, Wayne State University, 48202 Detroit, MI, U.S.A.;(2) Biosan Laboratories, Inc., 48220 Ferndale, MI, U.S.A. |
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Abstract: | Summary Evaluation of formaldehyde and fifteen biocides in formaldehyde sensitive (S) and resistant (R) strains ofPseudomonas aeruginosa revealed a pattern of response that allowed a comparison of the mode of action of these biocides. The response of these strains to the various biocides, as well as the induction of transient resistance or cross-resistance in the (S) strain, allowed a grouping of biocides based on this pattern of response. Group 1 biocides acted in a manner indistinguishable from formaldehyde for both the (S) and (R) strains. Group 2 biocides were not effective against either the (S) or (R) strains at concentrations calculated to release equimolar concentrations of formaldehyde. However, treatment of the (S) strain with formaldehyde or Group 2 biocides resulted in the development of cross-resistance. Group 3 biocides were equally effective against the (S) and (R) strain, but the (S) strain survivors of treatment with Group 3 biocides were resistant to formaldehyde. Group 4 biocides (controls) had no presumed connection to formaldehyde mode of action. These four groupings, based on pattern of response, also resulted in groupings of biocides based on chemical structure. |
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Keywords: | Biocides Formaldehyde-resistant bacteria Pseudomonas aeruginosa |
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