The interaction between calcium and the activation of Na+, K+-ATPase by noradrenaline |
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| Authors: | Marianne Haaga Wieland Gevers Reinhard G. Böhmer |
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| Affiliation: | (1) Dept. of Physiology, University of Pretoria, 0002 Pretoria;(2) Dept. of Analytical Chemistry, University of Pretoria, 0002 Pretoria;(3) Department of Medical Biochemistry, Medical School, U. C. T., Observatory 7925, Cape Town, Republic of South Africa;(4) Dept. of Physiology, University of Pretoria, P.O. Box 2034, 0001 Pretoria, Republic of South Africa |
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| Abstract: | Summary The interaction of noradrenaline, various cation chelators and calcium on Na+, K+-ATPase from rat cerebral cortex plasma membranes was studied. It was shown that chelation of inhibitory cations by EGTA, EDTA and dipyridyl activated Na+, K+-ATPase to the same extent as noradrenaline but at higher concentrations; increasing concentrations of EGTA depressed the activation by noradrenaline; calcium in the form of a calcium-EGTA buffer depressed Na+, K+-ATPase at physiological concentrations; the inhibition of Na+, K+-ATPase by calcium is dependent on the magnesium concentration in the assay and the inhibition by calcium was partially reversed by noradrenaline. |
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| Keywords: | Adenosine triphosphatase Na+ K+ catecholamines calcium |
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