Urinary excretion of C-20 reduction products of corticosterone and 11-dehydrocorticosterone |
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| Affiliation: | 1. School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea;2. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Raebareli, Lucknow, India;3. Department of Pharmacology, Indo Soviet Friendship College of Pharmacy (ISFCP), Moga, India;4. Regional Institute of Pharmaceutical Science & Technology, Agartala, India |
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| Abstract: | Three hundred milligrams of corticosterone was ingested by a healthy man on each of 2 days, and urine was collected for 48 hr. The urine was extracted with chloroform in the presence of β-glucuronidase. Three steroids with a glycol side chain and the Δ4-3-ketone group have been separated from the urine extract. These were identified as (I) 20β,21-dihydroxy-4-pregnen-3,11-dione; (II) 11β,20β,21-trihydroxy-4-pregnen-3-one; and (III) 11β,20α,21-trihydroxy-4-pregnen-3-one.Evidence is presented indicating the presence of compound I in the urine of a woman with hypopituitarism following ingestion of 11-dehydrocorticosterone; and of the compound II in urine collected from two men during periods of adrenocorticotropin injections. |
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