Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1 |
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| Authors: | Jun?Zhou,Ping?Zhu mailto:zhuping@fmmu.edu.cn" title=" zhuping@fmmu.edu.cn" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Jian?Li?Jiang,Qing?Zhang,Zhen?Biao?Wu,Xi?Ying?Yao,Hao?Tang,Ning?Lu,Yong?Yang,Zhi?Nan?Chen mailto:chcerc@fmmu.edu.cn" title=" chcerc@fmmu.edu.cn" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | (1) Department of Clinical Immunology, First Affiliated Hospital, Fourth Military Medical University, 17 Changlexilu, Xi'an, 710032, Shaanxi, P.R. of China;(2) Department of Cell Biology / Cell Engineering Research Center, Fourth Military Medical University, 17 Changlexilu, Xi'an, 710032, Shaanxi, P.R. of China;(3) Department of pharmacology, School of Medicine of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P.R. of China |
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| Abstract: | ![]()
Background During infection and inflammation, circulating blood monocytes migrate from the intravascular compartments to the extravascular compartments, where they mature into tissue macrophages. The maturation process prepares the cells to actively participate in the inflammatory and immune responses, and many factors have been reported to be involved in the process. We found in our study that CD147 played a very important role in this process. |
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