Transferrin subtypes and variants in Germany; Further evidence for a Tf null allele |
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Authors: | S Weidinger H Cleve F Schwarfischer W Postel J Weser A Görg |
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Institution: | (1) Institut für Anthropologie und Humangenetik der Universität München, Richard-Wagner-Str. 10/I, D-8000 München 2, Germany;(2) Lehrstuhl für Allgemeine Lebensmitteltechnolgie, Technische Universität München, D-8050 Freising-Weihenstephan, Germany |
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Abstract: | Summary Isoelectric focusing (IEF) with carrier ampholytes was used for the determination of transferrin C subtypes and transferrin B and D variants in a sample of 1125 unrelated individuals from Southern Germany. The observed TfC allele frequencies were Tf*C1=0.7872, Tf*C2=0.1365, and Tf*C3=0.0675. The rare C subtype C6 was observed twice. A new C subtype, called C10, was observed and identified by IEF with immobilized pH gradients. The rare C subtypes C4 and C8 were also studied by this method. TfB and TfD variants were found with a heterozygous frequency of 1.53%. One new TfD was found which is located between D1 and D2 and therefore named D1-2. Evidence for a Tf null allele was obtained in a child and the putative father; they were considered to be heterozygous for an allele Tf0. The theoretical exclusion rate for paternity examinations was calculated for the Tf system and found to be 17.95%. |
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