The roles of interleukin-1 and interleukin-1 receptor antagonist in antigen-specific immune responses |
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| Authors: | Kai-Wei Lin Shu-Ching Chen Fu-Hsiung Chang John T. Kung Brend Ray-Sea Hsu Dr. Rong-Hwa Lin |
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| Affiliation: | (1) Graduate Institute of Immunology, National Taiwan University, Taiwan, ROC;(2) Graduate Institute of Biochemistry, College of Medicine, National Taiwan University, Taiwan, ROC;(3) Institute of Molecular Biology, Academia Sinica, Taipei;(4) Division of Endocrinology and Metabolism, Chang-Gung Memorial Hospital, Lin-Kou Medical Center, Taoyuan;(5) AbGenomics Corporation, 2 Fl., No. 32, Lane 358, Juikuang Road, 114 Neihu, Taipei, Taiwan, ROC |
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| Abstract: | Despite evidence that interleukin (IL)-1 promotes the proliferation of some T helper 2 (Th2) cell clones in vitro, the physiological role of IL-1 in the regulation of antigen-specific immune responses remains undefined. Using a liposome-DNA delivery system, we transiently expressed IL-1 receptor antagonist (IL-1Ra) to suppress IL-1 functions at the site of the antigen-specific primary immune response. Our data indicate, for the first time, that IL-1Ra downregulates antigen-specific IL-4 and IgE responses, with concomitant enhancement of interferon- and IgG2a responses in vivo. In addition, IL-1 can promote Th2 development in an IL-4-independent manner in vitro. Thus, the balance between endogenous IL-1 and IL-1Ra during the primary immune response can be an important factor in determining the antigen-specific effector function of T cells. |
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| Keywords: | Interleukin-1 receptor antagonist Interleukin-1 Immune response T cell |
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