Functional and molecular insights into KSRP function in mRNA decay |
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| Authors: | Paola Briata Ching-Yi Chen Andres Ramos Roberto Gherzi |
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| Affiliation: | 1. Gene Expression Regulation Laboratory, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, 16132 Genova, Italy;2. Department of Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA;3. Molecular Structure Division, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;1. Faculty of Engineering and Information Technology, Centre of Health Technologies, University of Technology, Sydney, Australia;2. Faculty of Science, University of Technology, Sydney, Australia;3. Division of Cancer Research, Jacqui Wood Cancer Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK |
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| Abstract: | ![]()
KSRP is a single strand nucleic acid binding protein that controls gene expression at multiple levels. In this review we focus on the recent molecular, cellular, and structural insights into the mRNA decay promoting function of KSRP. We discuss also some aspects of KSRP-dependent microRNA maturation from precursors that are related to its mRNA destabilizing function. This article is part of a Special Issue entitled: RNA Decay mechanisms. |
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