Triterpenoid saponins from Eryngium yuccifolium ‘Kershaw Blue’ |
| |
Authors: | Ping Wang Wei Yuan Guangrui Deng Zushang Su Shiyou Li |
| |
Institution: | National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX 75962-6109, USA |
| |
Abstract: | Phytochemical investigation on the root of Eryngium yuccifolium ‘Kershaw Blue’ resulted in the isolation and identification of two new polyhydroxyoleanene saponins, named eryngioside M and eryngioside N, together with 15 known triterpenoid saponins eryngiosides A-L, 21β-angeloyloxy-3β-β-d-glucopyranosyl-(1 → 2)]-β-d-xylopyranosyl-(1 → 3)]-β-d-glucuronopyranosyloxyolean-12-ene-15α,16α,22α,28-tetrol, saniculasaponin III, and saniculasaponin II. Their structures were established by extensive spectroscopic and chemical analyses. Eryngioside M and saniculasaponin II showed week cytotoxicity against human non-small cell lung tumor cells (A549) with GI50 values of 37.5 ± 1.59 μM and 35.5 ± 1.11 μM, respectively. |
| |
Keywords: | Apiaceae Triterpenoid saponins Eryngiosides Cytotoxicity |
本文献已被 ScienceDirect 等数据库收录! |
|