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Eight new monoterpene acylglucosides from Sibiraea angustata |
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| Authors: | Zhangwei Wang Bin Li Shishan Yu Xuewen Lai Bo Liu Jie Chen Toshimitsu Hayashi |
| Affiliation: | 1. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;2. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;3. Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama 930-0194, Japan |
| Abstract: | Chemical investigation of the aqueous extract of the aerial portion of Sibiraea angustata led to the isolation of eight new monoterpene acylglucosides named sibiraglucoside A–H (1–8) and two known monoterpenes, sibiraic acid (9) and sibiskoside (10). Their structures were elucidated through extensive spectroscopic data analysis (including 1D and 2D NMR and HRESIMS experiments) and compared to literature data. In the in vitro bioassay, all of the compounds showed moderate hypolipidemic effects. |
| Keywords: | Monoterpene acylglucoside Sibiraglucoside A–H Hypolipidemic effect |
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