Quantitative structure-intestinal permeability relationship of benzamidine analogue thrombin inhibitor |
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| Authors: | Sugano K Yoshida S Takaku M Haramura M Saitoh R Nabuchi Y Ushio H |
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| Affiliation: | Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd, Shizuoka, Japan. suganokyh@chugai-pharm.co.jp |
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| Abstract: | The intestinal permeability of benzamidine analogue thrombin inhibitor is correlated with molecular volume, lipophilicity (calculated log P and IAM column capacity factor), hydrogen bond acidity/basicity and dipolarity. |
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