| 先天性巨结肠病结肠壁内P物质能神经的免疫电镜观察 |
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| 引用本文： | 曹福元,殷光甫,胡道松,夏谷良,王果,茹立强. 先天性巨结肠病结肠壁内P物质能神经的免疫电镜观察[J]. 中国组织化学与细胞化学杂志, 1999, 0(3) |
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| 作者姓名： | 曹福元 殷光甫 胡道松 夏谷良 王果 茹立强 |
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| 作者单位： | 同济医科大学神经生物学教研室(曹福元，殷光甫，茹立强)，同济医科大学神经生物学教研室(胡道松)，同济医院小儿外科!武汉430030(夏谷良，王果) |
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| 摘 要： | 本研究应用电镜免疫细胞化学方法，对小儿先天性巨结肠病结肠壁内含Ｐ物质（ＳＰ）神经进行了观察。结果发现：狭窄段与结肠扩张段相比较，狭窄段含ＳＰ神经元缺失，神经终末减少，含无颗粒囊泡的神经终末增多，而含小颗粒囊泡的神经终末相对较少。本研究在超微结构水平为先天性巨结肠病结肠壁内肽能神经成份的改变及其与临床症状的可能关系提供了形态学证据。
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| 关 键 词： | 先天性巨结肠病 免疫电镜 P物质 人 |
IMMUNOELECTRON MICROSCOPIC OBSERVATION OF SUBSTANCE P IMMUNOREACTIVE (SP IR) NERVES IN THE COLON OF PATIENTS WITH HIRSCHSPRUNG'S DISEASE |
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| Cao Fuyuan,Yin Guangfu,Hu Daosong, Xia Guliang, Wang Guo,Ru Liqiang. IMMUNOELECTRON MICROSCOPIC OBSERVATION OF SUBSTANCE P IMMUNOREACTIVE (SP IR) NERVES IN THE COLON OF PATIENTS WITH HIRSCHSPRUNG'S DISEASE[J]. Chinese Journal of Histochemistry and Cytochemistry, 1999, 0(3) |
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| Authors: | Cao Fuyuan Yin Guangfu Hu Daosong Xia Guliang Wang Guo Ru Liqiang |
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| Affiliation: | Cao Fuyuan,Yin Guangfu,Hu Daosong,* Xia Guliang,* Wang Guo,Ru Liqiang |
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| Abstract: | The ultrastructure of substance P (SP) neuron in the colon of patients with Hirschsprung's disease was investigated by using immunoelectron microscopic method. The results showed that the SP IR neurons were absent, the number of SP IR fiber and the terminal containing small granular vesicles were reductive in Auerbach's myenteric plexus of the narrow segment, while the number of small clear vesicle was relativeily higher as compared with the enlarged segment. The results provide an ultrastructural evidence for the relationship between the change of peptidergic nerve constituents in the colonic wall and the clinical symptoms in patients with Hirschsprung's disease. |
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| Keywords: | Hirchsprung's Disease Immunoelectron microscopy Substance P Human |
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