Anisakis simplex and Terranova sp.: Inhibition by larval excretory-secretory products of mitogen-induced rodent lymphoblast proliferation |
| |
Authors: | Richard Raybourne Robert S Desowitz Michael M Kliks Thomas L Deardorff |
| |
Institution: | Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaii, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, Hawaii 96816, U.S.A. |
| |
Abstract: | Execretory-secretory products were collected from supernatants of in vitro cultures of larval nematodes, Anisakis simplex (type I) and Terranova sp. (Hawaii type A). These materials were found to be more potent inhibitors of rodent lymphocyte blast transformation induced by concanavalin A and bacterial lipopolysaccaride than whole worm extracts of the same parasites. Inhibition of blast transformation was a result of cytostatic rather than toxic effects on proliferating lymphoid cells. The material(s) responsible for suppression are greater than 10,000 MW and are heat labile. |
| |
Keywords: | Nematodes parasitic Blast cell transformation inhibition of Excretory-secretory products Concanavalin A Lipopolysac-charide Fish |
本文献已被 ScienceDirect 等数据库收录! |