Arginine vasopressin in the caudate nucleus plays an antinociceptive role in the rat |
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| Authors: | Yang Jun Chen Jian-Min Liu Wen-Yan Song Cao-You Wang Cheng-Hai Lin Bao-Cheng |
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| Institution: | Institute for Pharmaceutical and Medical Science, Guangdong Bangmin Pharmaceutical Co. Ltd., Jianghai Distract, Jiangmen, Guangdong 529000, China. yj6676@yahoo.com |
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| Abstract: | Our previous work has shown that arginine vasopressin (AVP) regulates antinociception through brain nuclei rather than the spinal cord and peripheral organs. The present study investigated the nociceptive effect of AVP in the caudate nucleus (CdN) of the rat. Microinjection of AVP into the CdN increased pain threshold in a dose-dependent manner, while local administration of AVP-receptor antagonist-d(CH(2))(5)Tyr(Et)DAVP decreased pain threshold. Pain stimulation elevated AVP concentration in CdN perfuse liquid. CdN pretreatment with AVP-receptor antagonist completely reversed AVP's effect on pain threshold in the CdN. The data suggest that AVP in the CdN is involved in antinociception. |
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| Keywords: | Arginine vasopressin Vasopressin receptor antagonist Caudate nucleus Antinociception Rat |
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