Compounds Extracted from Phyllantus and Jatropha elliptica Inhibit the Binding of [3H]Glutamate and [3H]GMP-PNP in Rat Cerebral Cortex Membrane |
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| Authors: | Martini Lúcia H. Souza Carla R. Marques Patricia B. Calixto João B. Yunes Rosendo A. Souza Diogo O. |
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| Affiliation: | (1) Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, 90035-003 Porto Alegre, RS, Brazil;(2) Departamentos de Farmacologia, Brazil;(3) Química, Universidade Federal de Santa Catarina, Florianópolis, 88015-420 Florianópolis, SC, Brazil;(4) Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, 90035-003 Porto Alegre, RS, Brazil |
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| Abstract: | Glutamate is to be considered a nociceptive neurotransmitter and glutamatergic antagonists present antinoceptive activity. In this study we investigated the effects of the naturally occurring antinociceptive compounds rutin, geraniin and quercetine extracted from Phyllanthus, as well as the diterpene jatrophone, extracted from Jatropha elliptica on the binding of [3H]glutamate and [3H]GMP-PNP [a GTP analogue which binds to extracellular site(s), modulating the glutamatergic transmission] in rat brain membrane. Jatrophone inhibited [3H]glutamate binding and geraniin inhibited [3H]GMP-PNP binding. Quercetine inhibited the binding of both ligands. These results may indicate a neurochemical parameter possibly related to the antinoceptive activity of these natural compounds. |
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| Keywords: | Glutamate guanine nucleotides antinoception naturally-occurring compounds |
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