Effects of Notch glycosylation on health and diseases |
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Authors: | Yusuke Urata Hideyuki Takeuchi |
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Institution: | Department of Molecular Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan |
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Abstract: | Notch signaling is an evolutionarily conserved signaling pathway and is essential for cell-fate specification in metazoans. Dysregulation of Notch signaling results in various human diseases, including cardiovascular defects and cancer. In 2000, Fringe, a known regulator of Notch signaling, was discovered as a Notch-modifying glycosyltransferase. Since then, glycosylation—a post-translational modification involving literal sugars—on the Notch extracellular domain has been noted as a critical mechanism for the regulation of Notch signaling. Additionally, the presence of diverse O-glycans decorating Notch receptors has been revealed in the extracellular domain epidermal growth factor-like (EGF) repeats. Here, we concisely summarize the recent studies in the human diseases associated with aberrant Notch glycosylation. |
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Keywords: | EGF repeats human diseases Notch signaling O-glycosylation |
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