P57 (KIP2) polymorphisms and breast cancer risk |
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| Authors: | Y. Li R. C. Millikan Beth Newman Kathleen Conway E. T. Li |
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| Affiliation: | (1) Department of Epidemiology, CB #7400, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7400, USA Tel.: +1 919 966 7437, Fax: +1 919 966 2089, US;(2) Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892-2440, USA, US |
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| Abstract: | ![]()
A previous report in this journal has suggested that germline deletions in the proline-alanine-rich (PAPA-repeat) region of P57 (KIP2) are associated with increased risk of a variety of cancers, including breast cancer. We have analyzed the association of P57 PAPA-repeat deletion polymorphisms and breast cancer risk as part of a population-based case-control study of breast cancer. We have not observed an association between the presence of one or two copies of deletion polymorphisms in P57 and breast cancer risk (adjusted odds ratio: 1.1, 95% confidence interval: 0.6–2.0). Further investigation is necessary to determine the functional significance of P57 deletion polymorphisms and their potential relationship with disease. Received: 9 September 1998 / Accepted: 26 October 1998 |
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