Antibody production in packed bed reactors using serum-free and protein-free medium |
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| Authors: | R. Bliem R. Oakley K. Matsuoka R. Varecka V. Taiariol |
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| Affiliation: | (1) Baxter Hyland Division, 1978 W. Winton Avenue, 94545 Hayward, CA, USA;(2) Industrial Division, Bristol-Myers Squibb Co., P.O. Box 4755, 13221-4755 Syracuse, NY, USA |
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| Abstract: | The present work demonstrates the utility of packed bed reactors for the production of monoclonal antibody. We present data from a continuous process run for the production of over 100 grams of antibody, using serum-free medium. An additional pilot run also demonstrates the potential for continued antibody production under protein-free conditions, using a standard basal medium. |
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| Keywords: | animal cell culture hybridoma monoclonal antibody packed bed reactor continuous culture perfusion protein-free medium |
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