Sealing of the follicular lumen of the anterior pituitary gland of the male rat |
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| Authors: | Y. Mabuchi H. Maruyama T. Yashiro S. Tanida C. Kurono N. Honda H. Kato D.C. Herbert |
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| Affiliation: | aThe First Department of Anatomy, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya City, Aichi, 467, Japan;1Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1-Sugao, Takatsu-ku, Kawasaki-City, Kanagawa, 216, Japan;2The First Department of Anatomy, Jichi Medical School, 3311-1, Yakushiji, Minamikawachi-machi, Kawachi-Gun, Tochigi, 329-04, Japan;3Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7762, USA |
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| Abstract: | It is commonly accepted that follicular lumina of the adult rat anterior pituitary gland are tightly sealed by junctional complexes, especially tight junctions. In this report, we describe the presence of follicular lumina that are unsealed. Peroxidase (HRP) was used to study such structures and when injected through the femoral vein, was observed in association with a few follicular lumina, on their microvilli and around the cilia of folliculo-stellate cells. The existence of peroxidase-positive follicles clearly shows that follicles of the hypophysis are not always firmly sealed by tight junctions. The folliculo-stellate cells which faced the peroxidase-positive follicles displayed HRP deposits which were membrane bound within their cytoplasm. These findings suggest an absorptive function for the folliculo-stellate cells. |
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| Keywords: | Rat peroxidase anterior pituitary gland follicular lumen tight junctions folliculo-stellate cells |
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