Chemical modification of neamine |
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| Authors: | Tetsuo Suami Shigeru Nishiyama Yasuhide Ishikawa Shinichi Katsura |
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| Affiliation: | Department of Applied Chemistry, Faculty of Engineering, Keio University, Hiyoshi, Yokohama 223 Japan |
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| Abstract: | ![]()
The aminocyclitol antibiotic neamine has been modified by changing the configuration of one or two hydroxyl groups of the aminocyclitol moiety to elucidate the relationship between configuration and antimicrobial activity. 5-Epi-, 6-epi-, and 5,6-diepineamine have been prepared and their antimicrobial activity has been determined against several micro-organisms. |
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