Antidyslipidemic and antioxidant activity of the constituents isolated from the leaves of Calophyllum inophyllum |
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| Affiliation: | 1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226 001, U.P., India;2. Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow 226 001, U.P., India;3. Harcourt Buttler Technological Institute (HBTI), Kanpur, India;1. Key Laboratory of Tropical Biological Resources of Ministry Education, State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou 570228, China;2. School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;3. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang 550014, China;1. IRD, UMR 241, Centre Polynésien de Recherche sur la Biodiversité Insulaire, B.P. 529, 98713 Papeete, French Polynesia;2. B.P. 52832, 98716 Pirae, Tahiti, French Polynesia;3. Faculté de Pharmacie de Strasbourg, UMR 7200 – Laboratoire d’Innovation Thérapeutique BP 60024F – 67401 Illkirch cedex, France;4. Université de la Polynésie française, UMR 241. Centre Polynésien de Recherche sur la Biodiversité Insulaire, B.P. 6570 Faa’a, 98702 Faa’a, Tahiti, French Polynesia;1. Faculty of Applied Sciences, Universiti Teknologi MARA, Samarahan Campus 2, Jalan Meranek, Kota Samarahan, Sarawak, Malaysia;2. Centre for Drug Research, Universiti Sains Malaysia, Pulau Pinang, Malaysia;3. School of Chemical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia;1. Department of Mechanical Engineering, University College of Engineering Villupuram, Tamilnadu, 605103, India;2. Department of Mechanical Engineering, JKK Nattraja College of Engineering and Technology, Tamilnadu, 638183, India |
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| Abstract: | 
In continuation of our drug discovery program on Indian medicinal plants, we isolated bioactive compounds (1–5) from the leaves of Calophyllum inophyllum and evaluated their antidyslipidemic activity in triton induced hyperlipidemia model. The calophyllic acid (1A) and isocalophyllic acid (1B) mixture, canophyllic acid (4) and amentoflavone (5) showed dose dependent lipid lowering activity in in vivo experiments. The compounds 1A + 1B mixture and 3 also showed good in vitro antioxidant activity. |
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