MiR-328 Expression Is Decreased in High-Grade Gliomas and Is Associated with Worse Survival in Primary Glioblastoma |
| |
| Authors: | Zhifeng Wu Lihua Sun Hongjun Wang Jianshe Yao Chuanlu Jiang Wenhui Xu Zhengxiang Yang |
| |
| Affiliation: | 1. Department of Neurosurgery, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, People’s Republic of China.; 2. Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China.; 3. Department of Neurosurgery, the Affiliated Yixin People’s Hospital of Jiangsu University, Yixin, People’s Republic of China.; Beijing Tiantan Hospital, Capital Medical University, China, |
| |
| Abstract: | MicroRNAs, a group of small endogenous, noncoding RNAs, are aberrantly expressed in many human cancers and can act as oncogene or anti-oncogene. Recent evidence suggests that some miRNAs have prognostic value for tumors. MiR-328 is known as a tumor suppressor; however, its relationship with the clinicopathological features of glioblastoma (GBM) and its prognostic value has yet not been investigated. We found that expression of miR-328 was significantly decreased both in anaplastic and GBM cohorts and that low miR-328 expression also conferred poor survival in primary GBM (PGBM) patients. MiR-328 might, therefore, serve as an independent prognostic marker. Furthermore, expression profiles of miR-328-associated mRNAs were established via microarrays for 60 GBM samples. The ontology of the miR-328-associated genes was then analyzed, which identified gene sets tightly related to cell mitosis. In addition, ectopic expression of miR-328 inhibited U87 cell proliferation and induced U87 cell cycle arrest. In conclusion, this is the first report showing that miR-328 is associated with patient’s survival time and that miR-328 might serve as an independent prognostic biomarker for GBM. |
| |
| Keywords: | |
|
|
