One class of mutants with disturbed centromere cleavage and chromosome pairing in Sordaria macrospora |
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Authors: | Patrick J F Moreau Denise Zickler and G Leblon |
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Institution: | (1) Laboratoire de Génétique, Universit'e Paris-Sud, Centre d'Orsay, Bât 400, F-91405 Orsay Cedex, France |
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Abstract: | Summary Two recessive mutants spo76 and spo77, altered in U.V. sensitivity, protoplast regeneration and meiotic recombination were isolated in Sordaria macrospora. The suppression of the spo76 phenotype by spo77 suggests that they are involved in the same pathway. The asynaptic spo77 exhibits a rare synaptonemal complex (SC) with abnormally thick and double lateral elements (LE). In spo76, an early centromere cleavage leads to a meiotic arrest after metaphase I; SC are formed, but their discontinuous LE appear to be either unique or split into two thin LE. It is suggested that the corresponding wild-type functions are required for the sister chromatid cohesiveness. |
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