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| 自噬在细胞存活和死亡中的作用 | |
| 引用本文： | He T,Wang HJ,Tan YZ. 自噬在细胞存活和死亡中的作用[J]. 生理科学进展, 2008, 39(1): 37-40 |
| 作者姓名： | He T Wang HJ Tan YZ |
| 作者单位： | 复旦大学上海医学院人体解剖与组织胚胎学系,上海,200032 |
| 摘 要： | 自噬是亚细胞膜结构发生动态变化并经溶酶体介导对细胞内蛋白质和细胞器降解的过程.通过平衡细胞合成和分解代谢,自噬稳定细胞内环境,维持细胞的存活.然而,过度自噬可导致细胞发生Ⅱ型程序性细胞死亡.自噬与凋亡在细胞死亡过程中的关系十分密切.本文对自噬的过程及其在细胞存活和死亡中的作用作一综述. |
| 关 键 词： | 自噬 凋亡 细胞存活 细胞死亡 自噬 细胞存活 细胞死亡 作用 Cell Death Cell Survival 关系 凋亡 程序性 细胞发生 内环境 稳定 分解代谢 细胞合成 过平衡 过程 降解 细胞器 蛋白质 胞内 |
The roles of autophagy in cell survival and cell death |
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| He Tao,Wang Hai-Jie,Tan Yu-Zhen. The roles of autophagy in cell survival and cell death[J]. Progress in Physiological Sciences, 2008, 39(1): 37-40 | |
| Authors: | He Tao Wang Hai-Jie Tan Yu-Zhen |
| Affiliation: | Department of Anatomy and Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China. |
| Abstract: | Autophagy is a process in which the subcellular membrane structures undergo dynamic morphological changes that lead to degradation of cellular proteins and organelles by lysosomes. Autophagy stabilizes intracellular environment and maintains cell survival through balancing anabolic metabolism and catabolism. However, overactive autophagy may induce the type II programmed cell death. There is a close relationship between autophagy and apoptosis during cell death. This review focuses on the processes of autophagy and its roles in cell survival and cell death. |
| Keywords: | autophagy apoptosis cell survival cell death |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |