p38 MAPK信号传导通路

丝裂原活化蛋白激酶（ｍｉｔｏｇｅｎ－ａｃｔｉｖａｔｅｄｐｏｒｏｔｅｉｎｋｉｎａｓｅ，ＭＡＰＫ）介导了生长、发育，分裂，死亡，以及细胞间的功能同步等多种细胞生理功能，在哺乳动物细胞中已发现和克隆了ＥＲＫ、ＪＮＫ／ＳＡＰＫ，ＥＲＫ５／ＢＭＫ１和ｐ３８／ＲＫ四个ＭＡＰＫ亚族，这些新的ＭＡＰＫ介导了物理，化学反激，细菌产物，炎性细胞因子等多种刺激引起的细胞反应，ｐ３８亚族至少包括ｐ３８（α），ｐ３８β，ｐ

p38 MAPK signal transduction pathway

Mitogen-activated protein kinase (MAPK) involved in many cellular process,such as,cell growth, development,division, programmed cell death and coordination of cell functions, etc.So far,four subfamilies of MAP kinase which are ERK.JNK/SAPK.ERK5/BMKI and p38/RKhad been inedtified and cloned in mammalian cells.The MAPKs mediate cellular responses inducedby physical-chemical stresses,bacterial products and proinflammatory cytokines. p38 subfamilycomprises p38(a). p38p. p38r and p38 isoforms which are in common in high similarityin sequence,"TGY" dual phosphorylation motif, and activation by environmental stress-Thedifferences of these kinases are represented by differential tissue distribution, specific selection ofup-stream kinase and different action on substrate.However,the specific function of each isoformof p38 is awaiting further investigation.