Identification and functional analysis of NOL7 nuclear and nucleolar localization signals |
| |
| Authors: | Guolin Zhou Colleen L Doçi Mark W Lingen |
| |
| Institution: | (1) Departments of Pathology, Medicine and Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA |
| |
| Abstract: | Background NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number
of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased mRNA and protein expression has
been observed in tumors and cell lines. Reintroduction of NOL7 into cells resulted in significant suppression of in vivo tumor growth and modulation of the angiogenic phenotype. Further, NOL7 was observed to localize to the nucleus and nucleolus
of cells. However, the mechanisms regulating its subcellular localization have not been elucidated. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
