A two-dimensional mathematical model of percutaneous drug absorption |
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| Authors: | K?George K?Kubota Email author" target="_blank">EH?TwizellEmail author |
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| Institution: | (1) Aditi College,University of Delhi, Bawana, Delhi, 110 039, India;(2) Department of Mathematical Sciences, Brunel University, Uxbridge, UB8 3PH, Middlesex, U.K.;(3) Department of Pharmacoepidemiology, Faculty of Medicine, University of Tōkyō, 7-3-1 Hongo, Bunkyo-ku, 113-8655 Tōkyō, Japan;(4) Graduate School of Mathematical Sciences,University of Tōkyō, 3-8-1 Komaba, Meguro, 153-8914 Tōkyō, Japan |
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| Abstract: | Background When a drug is applied on the skin surface, the concentration of the drug accumulated in the skin and the amount of the drug
eliminated into the blood vessel depend on the value of a parameter, r. The values of r depend on the amount of diffusion and the normalized skin-capillary clearence. It is defined as the ratio of the steady-state
drug concentration at the skin-capillary boundary to that at the skin-surface in one-dimensional models. The present paper
studies the effect of the parameter values, when the region of contact of the skin with the drug, is a line segment on the
skin surface. |
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