Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes |
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| Authors: | D'Archivio Massimo Scazzocchio Beatrice Filesi Carmela Varì Rosaria Maggiorella Maria Teresa Sernicola Leonardo Santangelo Carmela Giovannini Claudio Masella Roberta |
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| Affiliation: | National Centre for Food Quality and Risk Assessment, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy. |
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| Abstract: | ![]()
The effect of oxLDL on CD36 expression has been assessed in preadipocytes induced to differentiate. Novel evidence is provided that oxLDL induce a peroxisome proliferator-activated receptor gamma-independent CD36 overexpression, by up-regulating nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2). The nuclear translocation of Nrf2 appeared to depend on PKC pathway activation. In adipocytes, the CD36 up-regulation may indicate a compensation mechanism to meet the demand of excess oxLDL and oxidised lipids in blood, reducing the risk of atherogenesis. Besides strengthening the hypothesis that oxLDL can contribute to the onset of insulin-resistance, data herein presented highlight the significance of oxLDL-induced CD36 overexpression within the cellular defence response. |
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| Keywords: | PPAR, peroxisome proliferator-activated receptor DMIX, differentiation mixture STS, staurosporine Nrf2, nuclear factor erythroid 2 (NF-E2)-related factor 2 4-HNE, 4-hydroxynonenal FA, fatty acids |
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