A Case of Fatal Strongyloidiasis in a Patient with Chronic Lymphocytic Leukemia and Molecular Characterization of the Isolate |
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| Authors: | Eshrat Beigom Kia Hamid Reza Rahimi Hossein Mirhendi Mohammad Reza Nilforoushan Ardeshir Talebi Farzaneh Zahabiun Hamid Kazemzadeh and Ahmad Reza Meamar |
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| Institution: | 1School of Public Health, Medical Sciences/ University of Tehran, Tehran, Iran.;2Al-Zahra Medical Centre, Isfahan University of Medical Sciences, Isfahan, Iran.;3School of Medicine, Iran University of Medical Sciences, Tehran, Iran. |
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| Abstract: | Strongyloides stercoralis is a human intestinal parasite which may lead to complicated strongyloidiasis in immunocompromised. Here, a case of complicated strongyloidiasis in a patient with chronic lymphocytic leukemia is reported. Presence of numerous S. stercoralis larvae in feces and sputum confirmed the diagnosis of hyperinfection syndrome in this patient. Following recovery of filariform larvae from agar plate culture of the stool, the isolate was characterized for the ITS1 region of ribosomal DNA gene by nested-PCR and sequencing. Albendazole therapy did not have cure effects; and just at the beginning of taking ivermectin, the patient died. The most important clue to prevent such fatal consequences is early diagnosis and proper treatment. |
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| Keywords: | Strongyloides stercoralis hyperinfection chronic lymphocytic leukemia ITS1 ribosomal DNA |
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