首页 | 本学科首页   官方微博 | 高级检索  
     


The role of gap junctions in trophoblastic cell fusion in the guinea-pig placenta
Authors:Dr. J. A. Firth  A. Farr  K. Bauman
Affiliation:(1) Department of Structural Biology, St. George's Hospital Medical School, Cranmer Terrace, SW17 ORE London, England;(2) Department of Anatomy, King's College, London, England
Abstract:Summary Fusion of cytotrophoblast cells in the guinea-pig placenta occurs at regions of plasma membrane interdigitation where the cells are attached to one another by complex arrays of gap junctions and desmosomes. Fusion begins at the gap junctions, which are lost in this process. The desmosomes play no obvious part in the fusion mechanism and remain after fusion as sites of attachment of syncytiotrophoblast membrane to itself. It is proposed that a major role of gap junctions in placental development is to bring trophoblast plasma membranes into a close relationship which may act as a starting point for cell fusion.
Keywords:Placenta  Guinea pig  Trophoblast  Cell fusion  Gap junctions
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号