Genetic characterization of mouse immunoglobulin allotypic determinants (allotopes) defined by monoclonal antibodies |
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Authors: | Chun-Ming Huang Marilyn Parsons Vernon T Oi Huei-Jen Su Huang Leonard A Herzenberg |
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Institution: | (1) Department of Genetics, Stanford University, School of Medicine, 94305 Stanford, California;(2) Present address: Cetus Palo Alto, Inc., 701 Welch Rd., 94 304 Palo Alto, California;(3) Present address: Department of Biochemistry, University of Washington, 98195 Seattle, Washington |
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Abstract: | We have generated a new series of monoclonal antibodies recognizing allotypic determinants on mouse IgG1, IgG2a, and IgG2b. In this communication we describe their reactivities with immunoglobulins of the inbred mouse strains. Comparison with serology charts indicates that many of these monoclonal antibodies detect allotypic specificities previously defined by conventional antisera; others define previously undescribed specificities. Strain and isotype distribution allows us to assign five new allotypic specificities to Igh-1 and three new specificities to Igh-3. In addition, on the basis of reactivity with the monoclonal antibodies, we have defined a new Igh haplotype in SWR/J mice, Igh
p.Abbreviations used in this paper Igh
immunoglobulin heavy chain
- SDS
sodium dodecyl sulfate |
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