| 双歧杆菌协同TIL细胞体内杀瘤活性的研究 |
| |
| 引用本文： | 史俊华,孙君江.双歧杆菌协同TIL细胞体内杀瘤活性的研究[J].中国微生态学杂志,1995,7(4):11-14. |
| |
| 作者姓名： | 史俊华 孙君江 |
| |
| 作者单位： | 南京铁道医学院微生物免疫室，南京第一医院中心实验室 |
| |
| 摘 要： | 本研究应用从小鼠Ｓ１８０癌性腹水分离诱导的ＴＩＬ癌内注射与活的双歧杆菌腹腔内注射共同治疗荷Ｓ１８０实体瘤小鼠，结果表明单用ＴＩＬ和ＴＩＬ合用ＩＬ－２早期抑瘤效果，能延缓肿瘤的发生和发展，而晚期抑瘤效果尚不及单用双歧杆菌组。ＴＩＬ与双歧杆菌、ＴＩＬ、双歧杆菌及低剂量ＩＬ－２，荷瘤早、晚期抑瘤效果均较好，且毒副作用低，表明双歧杆菌有可能通过刺激机产生内源性ＩＬ－２维持ＴＩＬ的生物学活性从而协同ＴＩＬ细
|
| 关 键 词： | 肿瘤 免疫疗法 双歧杆菌 TIL细胞 白细胞介素 |
STUDY ON ALTITUMOR EFFECT IN VIVO BY BIFIDOBACTERIUM WITH TILS |
| |
| SHI JUNHUA,et al..STUDY ON ALTITUMOR EFFECT IN VIVO BY BIFIDOBACTERIUM WITH TILS[J].Chinese Journal of Microecology,1995,7(4):11-14. |
| |
| Authors: | SHI JUNHUA |
| |
| Institution: | Nanjing Railway medieal college Nanjing 210009 |
| |
| Abstract: | In this study,bifidobacterium combined with TILs(tumorinfiltrating lympho-cytes)induced from S180 carcinomic was used to trest mice bearing S180 solid tumor. Bifidobac-teria were given intraperitoneally, TILs were injected into tumor-attacking position local-ly. It found that in early period, TILs ,TILs combined with IL-2 exhibited good anti-tu-mor effect,retarding tumor incidence and development;while in advanced period ,their anti-tumor were inferior to that of bifidobacteria. We also found that TILs with bifidobacteria,TILa bifidobacteria with small dose of IL-2(100/mouse)exhibited excellent anto -tumor effect in both early and advanced periods |
| |
| Keywords: | Bifidobacterium TILs(tumor infiltrating lymphocytes)IL-2(interleukin-2) |
| 本文献已被 CNKI 维普 等数据库收录！ |
