| Toll样受体(TLRs)的信号转导与免疫调节 |
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| 引用本文： | 王海坤,韩代书.Toll样受体(TLRs)的信号转导与免疫调节[J].生物化学与生物物理进展,2006,33(9):820-827. |
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| 作者姓名： | 王海坤 韩代书 |
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| 作者单位： | 中国医学科学院基础医学研究所,中国协和医科大学基础医学院细胞生物学系,北京,100005 |
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| 摘 要： | Toll样受体(Toll-like receptors,TLRs)是进化中比较保守的一个受体家族,至少包括10个成员.TLRs能特异地识别病原相关的分子模式(PAMPs),不仅在激活天然免疫中发挥重要的作用,而且还调节获得性免疫,是连接天然免疫和获得性免疫的桥梁.近年来,TLRs信号转导的研究,特别是在负调控研究领域,进展非常迅速.对TLRs信号通路新进展以及TLRs在抗感染免疫中的作用进行了综述.
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| 关 键 词： | Toll样受体 天然免疫 获得性免疫 信号转导 |
| 收稿时间： | 4/5/2006 12:50:06 AM |
| 修稿时间： | 6/8/2006 10:57:51 AM |
Toll-like Receptors Signaling and Regulation of Immune Response |
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| WANG Hai-Kun and HAN Dai-Shu.Toll-like Receptors Signaling and Regulation of Immune Response[J].Progress In Biochemistry and Biophysics,2006,33(9):820-827. |
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| Authors: | WANG Hai-Kun and HAN Dai-Shu |
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| Institution: | Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China;Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China |
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| Abstract: | Toll-like receptors (TLRs), a large family consisting of at least 10 members, are evolutionarily conserved to recognize pathogen-associated molecular patterns (PAMPs). TLRs activation not only initiates innate immunity, but also regulates enhance antigen-specific acquired immunity, and thus associates innate and adaptive immunity. In recent years, studies on the TLRs signaling, especially their negative regulation, rapidly progressed. TLRs signaling pathway and their roles in regulating immune responses against invading pathogens were reviewed. |
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| Keywords: | Toll-like receptor innate immunity adaptive immunity signal transduction |
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