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Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length |
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| Authors: | Mori Shuichi Miyake Shinya Kobe Takayoshi Nakaya Takaaki Fuller Stephen D Kato Nobuo Kaihatsu Kunihiro |
| Affiliation: | aThe Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan;bResearch Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan;cDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK |
| Abstract: | A series of fatty acid monoester derivatives of (−)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity 24-fold relative to native EGCG. |
| Keywords: | Epigallocatechin gallate Influenza virus Lipase-catalyzed esterification Antivirus agent |
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