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Metabolic plasticity drives development during mammalian embryogenesis
Institution:1. Department of Molecular, Cell and Developmental Biology, Los Angeles, CA 90095, USA;2. Molecular Biology Institute, Los Angeles, CA 90095, USA;3. Department of Biological Chemistry, Los Angeles, CA 90095, USA;4. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Los Angeles, CA 90095, USA;5. UCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA
Abstract:
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  • Keywords:preimplantation  redox  MYC  metabolic plasticity  embryo  developmental metabolism  zygotic genome activation  metabolic reprogramming  NAD+/NADH  reductive stress
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