Development of Lapachol Topical Formulation: Anti-inflammatory Study of a Selected Formulation |
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Authors: | Ana Amélia M Lira Elizângela A Sester André Luis M Carvalho Ruth R Strattmann Miracy M Albuquerque Almir G Wanderley Davi P Santana |
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Institution: | NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco, Brazil. |
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Abstract: | This study aimed at developing a topical formulation of lapachol, a compound isolated from various Bignoniaceae species and
at evaluating its topical anti-inflammatory activity. The influence of the pharmaceutical form and different types of emulsifiers
was evaluated by in-vitro release studies. The formulations showing the highest release rate were selected and assessed trough
skin permeation and retention experiments. It was observed that the gel formulation provided significantly higher permeation
and retained amount (3.9-fold) of lapachol as compared to the gel-cream formulation. Antinociceptive and antiedematogenic
activities of the most promising formulation were also evaluated. Lapachol gel reduced the increase in hind-paw volume induced
by carrageenan injection and reduced nociception produced by acetic acid (0.8% in water, i.p.) when used topically. These
results suggest that topical delivery of lapachol from gel formulations may be an effective medication for both dermal and
subdermal injuries. |
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Keywords: | gel gel-cream in-vitro permeation lapachol |
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