脂肪因子瘦素和内脂素与心房颤动关系的研究

摘要 目的：心房颤动（Atrial fibrillation，AF）是最常见的心律失常之一，其发生机制目前尚未完全阐明。多项研究表明脂肪因子（Adipokines）中的瘦素（leptin）、内脂素（Visfatin）与心血管疾病的关系密切，本研究拟探讨瘦素、内脂素与心房颤动的关系。方法：本研究通过收集检测AF组、窦性心律组外周血及心外膜脂肪组织，检测瘦素、内脂素分泌水平来探讨瘦素、内脂素与AF发生的相关性。结果：房颤组血清内脂素的平均浓度为15.95±10.44 ng/mL，窦性心律组为20.28±12.90 ng/mL（P=0.169）；房颤组血清瘦素的平均浓度为1.48 ng/mL，窦律组为2.56 ng/mL（P=0.0027），窦性心律组血清瘦素水平明显高于心房颤动组；心外膜脂肪组织中，瘦素在房颤组中的表达量显著低于窦性心律组（P=0.032），内脂素在两组中的表达无显著统计学差异（P=0.06）。结论：临床患者外周血血清及心外膜脂肪组织中高水平的瘦素可能降低房颤的发生率，然而，内脂素与房颤可能不具有相关性。

A Study on The Relationship between Leptin, Visfatin and Atrial Fibrillation

ABSTRACT Objective: Atrial fibrillation is one of the most common arrhythmias. The mechanism of atrial fibrillation is not yet clear. A number of previous studies have shown that adipokines, including leptin, visfatin, are closely related to cardiovascular diseases. In this study, the relationship between leptin, visfatin and atrial fibrillation was investigated. Methods: In this study, the secretion levels of leptin and visfatin in peripheral blood and epicardial adipose tissue of AF group and control group were detected. To explore the relationship between leptin, visfatin and AF. Results: The average concentration of visfatin in peripheral blood serum of atrial fibrillation group was 15.95±10.44 ng/mL, and the sinus rhythm group was 20.28±12.90 ng/mL, and there was not statistically significant (P=0.169); The average concentration of leptin in peripheral blood in the atrial fibrillation group was 1.48 ng/mL, and in the sinus rhythm group was 2.56 ng/mL. The comparison between the two was statistically significant (P=0.0027). Serum leptin levels in the sinus group were significantly higher than those in the atrial fibrillation group; In epicardial adipose tissue, the expression of leptin in the atrial fibrillation group was significantly lower than that in the control group (P=0.032), while the expression of visfatin was not statistically different between the two groups (P=0.06). Conclusion: The incidence of atrial fibrillation can be reduced by high levels of leptin in peripheral blood serum and epicardial adipose tissue. The levels of visfatin in peripheral blood serum and epicardial adipose tissue in patients with atrial fibrillation was not significantly different from those with sinus rhythm. Therefore there may not be a correlation between visfatin and atrial fibrillation.