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Macromolecular systems and bactericidal films based on chitin derivatives and silver nanoparticles |
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| Authors: | L. N. Shirokova V. A. Alexandrova E. M. Egorova G. A. Vihoreva |
| Affiliation: | (1) Topchiev Institute of Petrochemical Synthesis, Russian Academy of Medical Sciences, Leninskii pr. 29, Moscow, 119991, Russia;(2) Scientific Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia;(3) Kosygin Moscow Textile State University, Malaya Kaluzhskaya ul. 1, Moscow, 119071, Russia |
| Abstract: | A new polymer composite based on carboxymethylchitin and silver nanoparticles was obtained in order to produce biodegradable wound coating films. The number of metal nanoparticles in the composite may be easily regulated as was verified by UV-VIS-spectroscopy data. A comparative evaluation of silver nanoparticle size in the initial system and in the polymer composition was performed by means of photon correlation spectroscopy. Composite films revealed a pronounced concentration-dependent antibacterial activity towards strains Salmonella typhimurium and Staphilococcus aureus. |
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