Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet

Authors:	Kunimoto Koshi Yamazaki Yuji Nishida Tomoki Shinohara Kyosuke Ishikawa Hiroaki Hasegawa Toshiaki Okanoue Takeshi Hamada Hiroshi Noda Tetsuo Tamura Atsushi Tsukita Shoichiro Tsukita Sachiko

Affiliation:	1. Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan;2. Research Center for Ultra-high Voltage Electron Microscopy, Osaka University, Osaka 567-0047, Japan;3. Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University and CREST, Japan Science and Technology Corporation (JST), Osaka 565-0871, Japan;4. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA;5. Department of Hepatology, Saiseikai Suita Hospital, Osaka 564-0013, Japan;6. Department of Cell Biology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan;7. Department of Cell Biology, Faculty of Medicine, Kyoto University, Yoshida-Konoe, Kyoto 606-8315, Japan

Abstract:	Download : Download high-res image (480KB) Download : Download full-size image Highlights? Mice expressing truncated Odf2 cough and sneeze due to primary ciliary dyskinesia ? Full-length Odf2 is needed for the formation of basal body-associated basal feet ? In the absence of basal feet, basal bodies fail to align with planar polarity cues ? Polarization of basal bodies by Odf2 is required for coordinated ciliary beating

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