Macrophage activation for tumor cytotoxicity: genetic variation in macrophage tumoricidal capacity among mouse strains. |
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| Authors: | D Boraschi M S Meltzer |
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| Institution: | Immunopathology Section, Laboratory of Immunobiology, Immunology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 U.S.A. |
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| Abstract: | Development of activated tumoricidal macrophages following Mycobacterium bovis, strain BCG infection in vivo or lymphokine treatment in vitro was examined with more than 20 mouse strains. Peritoneal macrophages from 8 of 22 strains failed to develop tumoricidal capacity by 7 days after intraperitoneal BCG infection. Macrophages from 6 of 6 in vivo nonresponder strains also failed to develop tumoricidal capacity after in vitro treatment with lymphokines. Identification of nonresponder mouse strains should provide a useful resource for analysis of intermediary reactions in macrophage activation. |
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