Phage P22 helps phage MB78 to overcome blockage of DNA maturation in rifampicin-resistant host |
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| Authors: | Saeed Ahmad Khan Manzoor A Zargar Maharani Chakravorty |
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| Institution: | 1. Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University, 221 005, Varanasi, India
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| Abstract: | Bacteriophage MB78, a virulent phage ofSalmonella typhimurium cannot grow in rifampicin-resistant mutant (rif-39) of the host having altered RNA polymerase. The temperate phage P22 which
cannot multiply in presence of the virulent phage MB78 can, however, help MB78 to overcome replication inhibition in rif-39.
The processing of concatemeric phage DNA to monomer is blocked in this nonpermissive host. Superinfection with P22 induces
synthesis of at least five P22 specific polypeptides which help phage MB78 in the processing of the concatemeric DNA and maturation
of phage particles. |
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| Keywords: | Bacteriophage MB78 blockage in DNA maturation P22 as helper phage abortive infection |
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