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Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator |
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| Authors: | Lahm George P Stevenson Thomas M Selby Thomas P Freudenberger John H Cordova Daniel Flexner Lindsey Bellin Cheryl A Dubas Christine M Smith Ben K Hughes Kenneth A Hollingshaus J Gary Clark Christopher E Benner Eric A |
| Affiliation: | DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA. george.p.lahm@usa.dupont.com |
| Abstract: | Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented. |
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