Complete remission in a patient with acute myelogenous leukemia treated with leukocyte α-interferon and cimetidine |
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Authors: | Jaro Ankerst Roger Fäldt P G Nilsson Per Flodgren H O Sjögren |
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Institution: | (1) Department of Internal Medicine, University of Lund, Lund, Sweden;(2) Department of Internal Oncology, University of Lund, Lund, Sweden;(3) The Wallenberg Laboratory, University of Lund, Lund, Sweden |
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Abstract: | Summary A 76-year-old woman with acute myelogenous leukemia with approximately 65% myeloblasts on bone marrow examination was treated daily with a combination of 4 megaU of leukocyte interferon IM and 1,000 mg cimetidine PO. During therapy there was a gradual decrease of bone marrow myeloblasts down to 9% and a normalization of peripheral white blood cells. The treatment was discontinued after 6 weeks because of increasing fatigue and anorexia. The general condition improved greatly during the following weeks and the patient entered complete remission, which has continued for 6 months so far. In the course of therapy there was a gradual appearance of antibodies showing a selective binding capacity to autochthonous leukemic cells with no tendency to increased binding to remission cells. The aim of this report is to stimulate a further evaluation of this form of therapy in additional AML patients whenever this might be justified as an alternative to conventional chemotherapy. |
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